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The net medication-attributable GI event rate is roughly 25 to 30%, meaning about one in four people experience GI symptoms that would not have occurred without the medication
Osto E, Doytcheva P, Corteville C, Bueter M, Drig C, Stivala S, et al
demonstrated the effect of glucagon to stimulate beta-cell cAMP production specifically through the GCGR ( 2+ levels, and ERK1/2 activation ( 2+ levels in response to glucagon treatment, and dose-dependent activation of ERK1/2 ( Considering the functional and structural similarities between the GCGR and GLP-1R, it was predicted that glucagon mediated these insulinotropic effects through signaling at the beta-cell GCGR
JT: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review and editing
10.3892/or.2020.7582 283 LiuX.XieC.WangY.XiangJ.ChenL.YuanJ.et al (2024b)
